![]() ![]() These genes predicted COAD patient survival and modulated the tumor microenvironment, drug sensitivity and immune microenvironment. We identified four disulfidptosis-related genes: TRIP6, OXSM, MYH3 and MYH4. We also explored the potential biological functions and therapeutic implications of the disulfidptosis-related genes using CIBERSORTx and GDSC2 databases. We used machine learning to select key features and build a signature and validated the risk model using data from the Gene Expression Omnibus (GEO) database and Human Protein Atlas (HPA). We analyzed the mRNA expression data and clinical information of COAD patients from The Cancer Genome Atlas (TCGA) database and Xena databases, extracted disulfidptosis-related genes from the latest reports on disulfidptosis. ![]() We discovered genes associated with disulfidptosis in colon adenocarcinoma and proposed them as novel biomarkers and therapeutic targets for COAD. Disulfidptosis is a new mode of cell death that may affect cancer development. The outcome of COAD is determined by the tumor stage, location, molecular characteristics and treatment. COAD is influenced by various factors, including genetics, environment and lifestyle. Colon adenocarcinoma (COAD) is a type of cancer that arises from the glandular epithelial cells that produce mucus in the colon.
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